What role does DeltaFosb play? Gary?

Discussion in 'Pornography Addiction' started by bigproblem, Dec 12, 2013.

  1. bigproblem

    bigproblem New Member

    since i ve read before that people feel better after 6-8 weeks. Do they feel better in terms of not wanting anymore porn or their erection is better?

    Does this Deltafosb desensitize us to real women or just sensitizes us to porn?
  2. Gary Wilson

    Gary Wilson Active Member

    Definitely sensitizes you to porn. It also seems to allow greater consumption...at least with addictive drugs. It does this by affecting the frontal cortex, inhibiting the negative effects of the drug, at least for a while.

    QUOTE:These findings indicate that ΔFosB helps mediate tolerance to the cognitive-disrupting effects of cocaine. Users who experience tolerance to the deleterious effects of cocaine are more likely to become cocaine dependent, whereas those who find the drug more disruptive at work or school are less likely to become addicted Tolerance to the cognitive disruption caused by acute cocaine in cocaine-experienced individuals may therefore facilitate the maintenance of addiction. In this way, ΔFosB induction in the orbitofrontal cortex may promote an addicted state, similar to its actions in the nucleus accumbens where ΔFosB promotes addiction by enhancing the rewarding and incentive motivational effects of the drug.

    Everything I've seen does not link deltafosb to dopamine down regulation...at least directly. In animal experiments where rats gorged themselves on junk food, desensitization started withing days, which is too quick for deltafosb

    have you read this article? Porn, Pseudoscience and ΔFosB - http://yourbrainonporn.com/porn-pseudoscience-and-%CE%B4fosb
  3. Dopamine

    Dopamine New Member

  4. bigproblem

    bigproblem New Member

    so does deltafosb have anything to do with the 90 day or so brain being rebooted and the erection being better?
  5. Gary Wilson

    Gary Wilson Active Member

    Deltafosb breaks down slowly, so the estimates are that levels are back to normal after 2 months of abstinence. A few points:

    Deltafosb turns on certain genes, which then alter many aspects of nerve cell signaling in the reward circuit. This causes sensitization. These changes can and do persist after deltafiosb is long gone. These changes are the reason why an addict can relapse long after being sober...and then quickly progress to high levels of use. see - Why do porn cues still trigger a rush (sensitization)? http://www.yourbrainonporn.com/why-am-i-still-noticing-a-dopamine-rush-after-rebooting

    A lot of guys say they feel better after 2 months, but a lot of guys don't. The 90 day reboot is not a creation of YBOP. Reddit/Nofap created it, and it has nothing to do with anything. Many guys take 6-9 months or more to heal from PIED. How much a role sensitization plays in PIED is speculative.
  6. Carl90

    Carl90 New Member

    DeltaFosB is about cravings, right? Without DeltaFosB we wouldn't want more of the addictive substance, right?

    Am I right about this?
  7. Gary Wilson

    Gary Wilson Active Member

    Yes. Although it may be involved with more than that.
  8. Carl90

    Carl90 New Member

    Thanks Gary. Keep up the good work mate :)
  9. bigproblem

    bigproblem New Member


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